You’ve probably seen those movies or heard where someone is kidnapped using a mysterious cloth being pressed over the victim’s mouth and nose. Ever wondered the magic behind it? Well, it’s not entirely magic as this cloth contains a medical anesthesia called chloroform.
The cloth was probably soaked in this liquid and used to carry out this act. But how did this once-revolutionary medical anesthetic become associated with such sinister acts?

A Brief Background History on Chloroform
Chloroform (trichloromethane) is a dense, sweet-smelling liquid that quickly evaporates. Its chemical formula is CHCl₃, which simply means that it is made up of three chlorine atoms, one hydrogen atom, and one carbon atom.
Chloroform is a colorless liquid which is a known choice for calming down patients during surgery. Doctors first learned about the benefits of chloroform for medicine in the 1800s. Back then, it could put people to sleep, which would help with surgery and child deliveries. It was first seen as beneficial since it made it possible for doctors to operate on patients with more precision and less pain.
However, doctors soon discovered that chloroform had some health risks, like breathing problems, heart problems, and its potential to cause cancer. As a result, it has became closely regulated. Even though it’s not used much in medicine anymore, it’s still used in the laboratory and industry.
How Does Chloroform Affect The Human Body?
Remember the case scenario discussed in the introduction, in which people are kidnapped using a chloroform-filled cloth. In a case like that where such a cloth is placed over a victim’s nose, the person inhales. Once that happens, it quickly gets into their bloodstream through their lungs.
Chloroform targets the central nervous system, where it acts as a depressant. This means it slows down brain activity, and causes sleepiness, dizziness, and eventually, it knocks them out. It does this by messing with nerve cell functions, which reduces their ability to communicate with each other.
This mechanism is what made chloroform useful as an anesthetic in the past. High doses can slow down a person’s breathing and heart rate so much that it can cause respiratory failure or even cardiac arrest.
What Are the Effects of Chloroform Exposure?
We’ve already discussed the effects of chloroform on the body. But this section is going to highlight them in case you missed them earlier. Chloroform can have two types of effects on the body: Short term effects and long term effects.
Short-Term Effects
- Dizziness
- Nausea
- Vomiting
- Headache
- Breathing problems
- Irregular heartbeats
Long-Term Effects
- Liver damage
- Kidney damage
- Brain damage
- Increased cancer risk
How Can You Safely Handle Chloroform?
First off, it needs to be stored properly; usually in a cool, dark place, and always sealed tightly. When using chloroform, ventilation should be your priority, in order to prevent inhaling too much of it.
If you do get exposed to it, get to fresh air immediately, seek medical help, and follow safety protocols like washing off the affected area (eyes or skin), evacuating the area (when there’s a spill), using absorbent material like sand to absorb spill, in order to minimize harm.
Bottom Line
Chloroform has had a wild journey from being a medical game-changer to something you only see in crime movies. While it helped doctors perform surgeries without pain back in the day, its serious health risks have led to strict rules about its use.