Plymouth Argyle, who upset Liverpool with a 1-0 home win in the cup tie of the round, and were drawn against defending Premier League champions Manchester City in the fifth round. At the foot of the Championship, the Pilgrims pulled off one of the biggest upsets in F.A. Cup history on Sunday when they sent the Premier League leaders crashing out.
City, who scraped past Leyton Orient 2-1 in the last round, have struggled for that elusive consistency this term but they are still very much a banana skin draw for the giant-killers.
Holders Manchester United will host Fulham at Old Trafford in one of at least three all-English matchups. League Cup finalists Newcastle United will host Brighton & Hove Albion, while Bournemouth will battle against Wolverhampton Wanderers in the other encounter between top-flight teams.
Aston Villa, who knocked out Tottenham Hotspur, will host second-tier Cardiff City and Crystal Palace will entertain South London rivals Millwall in a mouthwatering derby.
There is the potential for a fourth all-Premier League tie if Nottingham Forest defeat the League One side Exeter City on Tuesday, with Ipswich Town waiting for the winner.
Fifth-round matches will be played over the weekend of March 1 and 2.
FA Cup Fifth-Round Draw
- Preston North End vs Burnley
- Aston Villa vs Cardiff City
- Manchester United vs Fulham
- Newcastle United v Brighton & Hove Albion
- Manchester City v Plymouth Argyle
- Crystal Palace vs Millwall
- Exeter City/Nottingham Forest vs Ipswich Town
